Mucinex Maximum Strength Nightshift Cold and Flu 20 Caplets Fast Release Caplets. Powerful Nighttime Multi Symptom Cold and Flu Relief! Mucinex Nightshift Cold and Flu Medicine provides multi symptom relief that controls your symptoms to help you get to sleep. Nighttime caplets relieve headache, body pain, cough, sneezing, runny nose, and reduces fever so you can get to sleep.