Shiseido Benefiance Wrinkle Smoothing Cream 1.8oz / 50ml Focus on the neuroscience of your skin's senses. With this rich, silky cream, ReNeura Technology directs internal sensory signals, to make skin optimally responsive to the age-defying benefits of skincare. It visibly smoothes out wrinkles, plumps up lines, and deeply moisturizes intensively to capture a youthfully radiant look.